Endocrine Abstracts

Introduction: Primary congenital hypothyroidism is the most common neonatal endocrine disorder, traditionally subdivided into thyroid dysgenesis, referring to a range of abnormalities in thyroid development, and dyshormonogenesis. We report two cases of dyshormonogenesis in a brother and sister followed for congenital hypothyroidism by inactivating mutation of the TSH receptor, illustrating the good evolution in case of an adapted treatment.Clinical case...

Introduction: Teratomas are complex malformative tumors defined by the presence of tissues derived from the 3 embryonic layers. They can be mature or immature, depending on their degree of differentiation. They are most often found in the sacrococcygeal region and the gonads. Cervical location is exceptional (4%).Observation: We report the case of a 45-year-old patient who presented with a right cervical swelling that progressively increased in volume. T...

Introduction: The occurrence of thyroid cancer in Basedow disease is rare. We report a series of five cases of patients with Basedow disease who were operated on and whose pathological examination showed an association with differentiated thyroid cancer.Clinical cases: We report a series of five patients with a mean age of 39 years. The diagnosis of Basedow disease was made on the basis of clinical, biological and scintigraphic evidence. Cervical ultraso...

Introduction: Liver dysfunction during hyperthyroidism may be secondary to thyrotoxicosis, to an associated liver pathology, or to the medical treatment of hyperthyroidism posing a problem of etiological diagnosis. In this context, we report a demonstrative observation.Case presentation: We report the observation of a 23-year-old female patient, followed for Basedow disease under carbimazole since 1 year, not controlled under medical treatment. During he...

Introduction: Most pituitary adenomas are benign. However, there are invasive forms with rapid growth rate and particular histological signs (atypical adenomas), making them considered pituitary carcinomas without metastases.Observation: A 63-year-old patient was followed for 10 years for Cushing’s disease in the pituitary macrodenoma. Clinical evaluation found Cushing syndrome, pituitary tumor syndrome associated with diplopia, and trigeminal neura...

Introduction: Epstein-Barr virus (EBV) is a well-known human tumor virus with a very high prevalence in the population, this virus is associated with epithelial and lymphoid malignancies, including lymphoepithelioma carcinoma of thyroid. This subtype of thyroid carcinoma is characterized by histologic features similar to those of undifferentiated carcinoma of the thyroid. Case Report: A 17-year-old male patient, his medical and family histories were non-...

Introduction: Partial 21-hydroxylase deficiency is a genetic autosomal recessive disorder responsible for accumulation of the precursor upstream of the enzyme block, 17-hydroxyprogesterone (17OHP), and excessive androgen production.Observation: A 29-year-old woman consulted for hirsutism with a Ferriman–Gallwey score of 25. There were no signs of Cushing syndrome and no abnormalities of sexual development. The Laboratory results revealed testosteron...

Introduction: Hypercalcemia is often observed in patients with cancer, secondary to the production s of parathyroid hormone (PTH)-related peptides. However, the association of primary hyperparathyroidism (pHPT) and colon cancer is rarely reported.Case: We present the case of a 76 years old female patient, who was operated one year ago of for a low-grade colorectal adenocarcinoma. As part of her routine workup of her disease she underwent a phosphocalcic ...

Introduction: Diabetic peripheral neuropathy (DPN) is a frequent complication of diabetes mellitus. The aim of our work is to determine the prevalence as well as the predictive factors of this degenerative complication and as a secondary endpoint the evaluation of the risk factors associated with painful diabetic neuropathy.Methods: This is a retrospective and prospective cross-sectional study with descriptive and analytical aims conducted over a period ...

Introduction: Acromegaly is an unusual endocrinopathy due to hypersecretion of growth hormone (GH) and concomitant rise of IGF-1. It is associated with premature of mortality caused by cardiovascular, respiratory and metabolic diseases, as well as increased risk of developing boh benign and malignant tumours. We report the case of a patient with acromegaly associated with papillary thyroid microcarcinoma (PTC).CASEA 50-years -old m...